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| c. 208 |
| | | Ardashir is crowned king of Fars - a first step towards his founding of the Sassanian dynasty in Persia | |
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| 221 |
| | | The Han dynasty is brought to an end, after more than four centuries, by decades of peasant unrest | |
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| c. 230 |
| | | Ardashir, the Persian king, commissions a relief of himself in triumphant mood - carved high on a rock face at Naqsh-e Rustam | |
|  | Naqsh-e-Rustam
Fotofile CG
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| c. 232 |
| | | A house in Doura-Europus is adapted for Christian worship - the earliest surviving example of its kind | |
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| c. 244 |
| | | Plotinus, moving from Alexandria to Rome, teaches the influential philosophy later known as Neo-Platonism | |
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| c. 245 |
| | | Origen, living in Caesarea, compiles the Hexapla, displaying versions of the Old Testament in six columns for comparative study | |
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| c. 250 |
| | | Roman socks, surviving in dry Egyptian tombs, are the earliest known examples of knitting | |
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| c. 250 |
| | | The Goths split into two major groups, the Visigoths northwest of the Black Sea and the Ostrogoths further east | |
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| c. 250 |
| | | The Persian prophet Mani establishes the dualistic Manichaean religion | |
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| c. 250 |
| | | The Christians of Rome use the catacombs as tomb chambers, and decorate the walls with murals on New Testament themes | |
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